Sample

M. phlei (mm)^a

CYP17 inhibition (%)^b

POP inhibition (%)^c

Ca²⁺-signal (mm)^d

PP2C inhibition (%)^e

Cytotoxicity (μM)^f

Inhibition inner diam.

Partial inhibition outer diam.

Growth diam.

Inhibition diam.

HL60 cells

K562 cells

A

-

-

18

13

-

-

−16

4.46

36.0

B

-

-

14

0

-

-

−9

45.0

60.6

C

12.8

21.3

16

2

20.1

10.5

92

4.14

6.05

(IC₅₀ = 56.4 μM)

D

10.5

-

19

79

14.4

12.0

−30

30.3

6.05

(IC₅₀ = 26.0 μM)

E

13.6

19.6

53

29

15.2

14.7

4

3.94

5.15

F

-

-

11

29

14.2

9.3

−11

39.9

18.5

G

-

-

2

25

-

-

−17

42.4

>64.9

H

-

-

0

8

-

-

−8

37.6

34.7

Control

14.6 - 14.8 ^a

63 ^b

IC₅₀ = 0.55 μM^c

17.8 ^d

-

IC₅₀ = 2.50 μM^e

0.02

0.10